EPS8.04 Effects of a high-intensity interval training or moderate-continuous intensity training on exercise capacity and body composition in people with cystic fibrosis – a randomized controlled study

Objectives: The aim of this ongoing randomized-controlled study is to examine the effects exercise training interventions with different intensities on peak capacity and body composition in adult people Cystic Fibrosis (pwCF). Methods: Up now 17 pwCF (10f/7 m) mean age 35 ± 5yrs (22–57yrs), ppFEV1 66.0 16.3%pred. (43.0–99.0%pred.) participated. Cycle-ergometry (Godfrey-protocol) was used determine oxygen uptake (VO2peak) workload (Wpeak). Bioelectrical impedance analysis (BIA) assess composition. Patients were randomly matched either High-Intensity Interval Training (HIIT) or Moderate- Intensity Continuous (MICT) group stratified by lung disease severity (i.e., 40–70% pred. >70% pred.). frequency 3 sessions/week for 4 weeks a cycle ergometer (HIIT: intensity 10 bouts 1 min, 90% VO2peak followed active rest 2 min 40% VO2peak; MICT 30 constant load 60% VO2peak). data assessed during 4-week in-patient rehabilitation course two specialised CF institutions. Results: In both groups intervention had slight, non-significant (p > .05) ppFEV1, weight, BMI aspects statistical revealed an improvement Wpeak (VO2peak +15.4%, +12.4%, p < but only minor changes seen HIIT +8.0%, +1.2%, .05). Conclusion: seem have similar clinical outcomes capacity. This could be explained due lower at baseline that might led higher parameters such as Wpeak. No adverse observed neither after nor HIIT, suggesting programs are feasible pwCF. However, small number cases, results should interpreted caution.